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Cymbalta / Duloxetine - Depression Prescription Medication
Why is Cymbalta / Duloxetine prescribed?
Cymbalta / Duloxetine is an Online Pharmacy Medicine used to treat depression and generalized anxiety disorder (GAD; excessive worry and tension that disrupts daily life and lasts for 6 months or longer). Cymbalta / Duloxetine is also used to treat pain and tingling caused by diabetic neuropathy (damage to nerves that can develop in people who have diabetes) and fibromyalgia (a long-lasting condition that may cause pain, muscle stiffness and tenderness, tiredness, and difficulty falling asleep or staying asleep). Cymbalta / Duloxetine is in a class of medications called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). It works by increasing the amounts of serotonin and norepinephrine, natural substances in the brain that help maintain mental balance and stop the movement of pain signals in the brain.
How should Cymbalta / Duloxetine be used?
Cymbalta / Duloxetine comes as a delayed release (long-acting) capsule to take by mouth. When Cymbalta / Duloxetine is used to treat depression, it is usually taken once or twice a day with or without food. When Cymbalta / Duloxetine is used to treat generalized anxiety disorder, the pain of diabetic neuropathy, or fibromyalgia, it is usually taken once a day with or without food. Take Cymbalta / Duloxetine at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Cymbalta / Duloxetine exactly as directed. Do not take more or less of it, take it more often, or take it for a longer time than prescribed by your doctor.
Swallow the capsules whole; do not split, chew, or crush them. Do not open the capsules and mix the contents with liquids or sprinkle the contents on food.
If you are taking Cymbalta / Duloxetine to treat generalized anxiety disorder, the pain of diabetic neuropathy, or fibromyalgia, your doctor may start you on a low dose of medication and gradually increase your dose.
Cymbalta / Duloxetine may help control your symptoms but will not cure your condition. It may take 1 to 4 weeks or longer before you feel the full benefit of Cymbalta / Duloxetine. Continue to take Cymbalta / Duloxetine even if you feel well. Do not stop taking Cymbalta / Duloxetine without talking to your doctor. Your doctor will probably decrease your dose gradually. If you suddenly stop taking Cymbalta / Duloxetine, you may experience withdrawal symptoms such as nausea; vomiting; diarrhea; anxiety; dizziness; tiredness; headache; pain, burning, numbness, or tingling in the hands or feet; irritability; difficulty falling asleep or staying asleep; sweating; and nightmares. Tell your doctor if you experience any of these symptoms when your dose of Cymbalta / Duloxetine is decreased.
Other uses for Cymbalta / Duloxetine:
Cymbalta / Duloxetine is also sometimes used to treat stress urinary incontinence (leakage of urine during physical activity such as coughing, sneezing, laughing, and exercise) in women. Talk to your doctor about using this medication to treat your condition.
Cymbalta / Duloxetine may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow while using Cymbalta / Duloxetine?
Before taking Cymbalta / Duloxetine:
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tell your doctor and pharmacist if you are allergic to Cymbalta / Duloxetine or any other medications.
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tell your doctor if you are taking thioridazine or a monoamine oxidase (MAO) inhibitor, such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking an MAO inhibitor within the past 14 days. Your doctor will probably tell you not to take duloxetine. If you stop taking Cymbalta / Duloxetine, you should wait at least 5 days before you start to take an MAO inhibitor.
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tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin); antidepressants such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adapin, Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); antihistamines; aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); cimetidine (Tagamet); diuretics ('water pills'); linezolid (Zyvox); medications for irregular heartbeat such as amiodarone (Cordarone), flecainide (Tambocor), moricizine (Ethmozine), propafenone (Rythmol), and quinidine (Quinidex); medications for anxiety, high blood pressure, mental illness, pain, and nausea; propranolol (Inderal); medications for migraine headaches such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig); lithium (Eskalith, Lithobid); proton pump inhibitors such as lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), and rabeprazole (Aciphex); quinolone antibiotics such as ciprofloxacin (Cipro) and enoxacin (Penetrex); sedatives; certain selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox) and paroxetine (Paxil); sibutramine (Meridia); sleeping pills; theophylline (Theochron, Theolair); tramadol (Ultram); and tranquilizers. Many other medications may interact with Cymbalta / Duloxetine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
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tell your doctor what herbal products you are taking, especially products containing St. John's wort or tryptophan.
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tell your doctor if you have or have ever had glaucoma (an eye condition). Your doctor may tell you that you should not take Cymbalta / Duloxetine.
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tell your doctor if you drink or have ever drunk large amounts of alcohol or if you use or have ever used street drugs or have ever overused prescription medications. Also tell your doctor if you have or have ever had a heart attack; high blood pressure; seizures; coronary artery disease (blockage or narrowing of the blood vessels that lead to the heart; or heart, liver, or kidney disease. If you have diabetes, be sure to talk to your doctor about how serious your condition is so your doctor can decide if Cymbalta / Duloxetine is right for you.
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tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Cymbalta / Duloxetine, call your doctor.
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if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Cymbalta / Duloxetine.
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you should know that Cymbalta / Duloxetine may make you drowsy,dizzy, or may affect your judgment, thinking or coordination. Do not drive a car or operate machinery until you know how this medication affects you.
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ask your doctor about the safe use of alcoholic beverages while you are taking duloxetine. Alcohol can increase the risk of serious side effects from Cymbalta / Duloxetine.
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you should know that Cymbalta / Duloxetine may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking Cymbalta / Duloxetine or with an increase in dose. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
What special dietary instructions should I follow while using Cymbalta / Duloxetine?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do if I forget a dose of Cymbalta / Duloxetine?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can Cymbalta / Duloxetine cause?
Cymbalta / Duloxetine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of the following side effects, or those mentioned in the IMPORTANT WARNING section, call your doctor immediately:
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unusual bruising or bleeding
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pain in the upper right part of the stomach
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swelling of the abdomen
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itching
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yellowing of the skin or eyes
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dark colored urine
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loss of appetite
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extreme tiredness or weakness
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confusion
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flu-like symptoms
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blurred vision
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fever
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blisters or peeling of skin
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rash
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hives
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difficulty breathing or swallowing
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swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
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hoarseness
Cymbalta / Duloxetine may cause other side effects. Call your doctor if you have any unusual problems while taking Cymbalta / Duloxetine.
What storage conditions are needed for Cymbalta / Duloxetine?
Keep Cymbalta / Duloxetine in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
Symptoms of overdose of Cymbalta / Duloxetine may include:
What other information should I know about Cymbalta / Duloxetine?
Keep all appointments with your doctor.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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